From 22 to 24 October, several members of our team participated in the World Stroke Congress (WSC) held in Barcelona, showcasing a total of two oral presentations and four e-posters. These contributions reflect the group’s growing leadership in genetics, epigenomics, and multi-omics research in stroke.
Oral Presentations
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Paula Boldo presented “Sex-Stratified Genetic Risk of Stroke: Findings from an X-chromosome-wide association study.” Her presentation explored how X-chromosome genetic variants contribute differently to stroke risk in men and women, shedding new light on sex-specific disease mechanisms. This work has been carried out as part of the GEN-X project funded by La Marató.
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Cristina Gallego Fàbrega delivered the talk “How epigenomics & biological age impact stroke + exploring epigenetic drugs as future therapeutics.” She discussed the influence of biological ageing and epigenomic regulation on stroke, highlighting the therapeutic potential of targeting epigenetic pathways.
E-Poster Presentations
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Elena Muiño, in collaboration with Paula Villatoro, presented “Single-cell RNA sequencing shows endothelial transcriptomic changes in CADASIL patients.” This work leveraged single-cell RNA-seq to identify transcriptomic alterations in endothelial cells from patients with CADASIL, offering insights into vascular dysfunction.
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Laia Llucià showcased “A case-control proteomic study using the Olink Explore panel identifies 640 proteins associated with stroke risk.” Her study identified extensive proteomic signatures associated with stroke susceptibility, emphasizing the potential of protein biomarkers.
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Laia Mariné presented “Epigenomics Insights into Post-Stroke Respiratory Infections: a DNA Methylation Study.” This research uncovered DNA methylation patterns linked to respiratory infections after ischemic stroke.
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Cristina Gallego contributed an additional e-poster titled “Differential Methylation and Variability Methylation reveal specific stroke-associated epigenetic signatures.”Her findings reveal distinct epigenetic alterations that may influence stroke risk and functional outcomes.
