L6 Lipids and Stroke
According to numerous observational studies and randomized controlled trials, low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular disease, including myocardial infarction, peripheral vascular disease, and stroke. Other studies, however, have described an inverse association between the plasma level of LDL-C and the risk of hemorrhagic stroke. The mechanism by which dyslipidemias are associated with coronary heart disease has been widely studied. However, the mechanism underlying the association between cholesterol and stroke is not well established and could present significant differences due to the peculiar structure of the cerebral arteries and the peculiarities of cerebral metabolism.
Our goal is to apply genomic analysis techniques to detect genes and lipid metabolism pathways involved in the risk and prognosis of different types of stroke, identify potential therapeutic targets and thus improve stroke prevention and treatment.
